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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN6
All Species:
24.85
Human Site:
Y306
Identified Species:
49.7
UniProt:
P29350
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29350
NP_002822.2
595
67561
Y306
S
D
Y
I
N
A
N
Y
I
K
N
Q
L
L
G
Chimpanzee
Pan troglodytes
XP_001163468
596
67703
Y307
S
D
Y
I
N
A
N
Y
I
K
N
Q
L
L
G
Rhesus Macaque
Macaca mulatta
XP_001110915
597
67615
Y308
S
D
Y
I
N
A
N
Y
I
K
N
Q
L
L
G
Dog
Lupus familis
XP_543844
595
67669
Y306
S
D
Y
I
N
A
N
Y
V
K
N
E
L
L
G
Cat
Felis silvestris
Mouse
Mus musculus
P29351
595
67540
Y306
S
D
Y
I
N
A
N
Y
V
K
N
Q
L
L
G
Rat
Rattus norvegicus
P81718
613
69560
Y308
S
D
Y
I
N
A
N
Y
V
K
N
Q
L
L
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519010
556
61792
L268
T
F
D
S
L
T
D
L
V
E
H
F
K
R
T
Chicken
Gallus gallus
Q90687
593
67964
Y304
P
N
E
P
V
S
D
Y
I
N
A
N
I
I
M
Frog
Xenopus laevis
NP_001085766
594
68095
D304
D
E
S
I
A
G
S
D
Y
I
N
A
N
Y
I
Zebra Danio
Brachydanio rerio
NP_956254
589
66986
V300
E
N
A
D
P
N
V
V
G
S
D
Y
I
N
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29349
845
92957
E436
S
M
A
E
R
E
R
E
R
E
R
E
M
F
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784121
533
60826
L245
F
E
E
E
F
E
A
L
Q
L
L
D
N
K
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
97.8
96.1
N.A.
94.4
91
N.A.
68
54.2
58.3
64.7
N.A.
33.8
N.A.
N.A.
43.3
Protein Similarity:
100
98.8
98.4
97.9
N.A.
98.1
94.9
N.A.
72.9
70.7
72
78.4
N.A.
46.9
N.A.
N.A.
60.8
P-Site Identity:
100
100
100
86.6
N.A.
93.3
93.3
N.A.
0
13.3
13.3
0
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
33.3
46.6
26.6
20
N.A.
26.6
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
17
0
9
50
9
0
0
0
9
9
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
50
9
9
0
0
17
9
0
0
9
9
0
0
0
% D
% Glu:
9
17
17
17
0
17
0
9
0
17
0
17
0
0
0
% E
% Phe:
9
9
0
0
9
0
0
0
0
0
0
9
0
9
0
% F
% Gly:
0
0
0
0
0
9
0
0
9
0
0
0
0
0
50
% G
% His:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
9
% H
% Ile:
0
0
0
59
0
0
0
0
34
9
0
0
17
9
9
% I
% Lys:
0
0
0
0
0
0
0
0
0
50
0
0
9
9
9
% K
% Leu:
0
0
0
0
9
0
0
17
0
9
9
0
50
50
0
% L
% Met:
0
9
0
0
0
0
0
0
0
0
0
0
9
0
9
% M
% Asn:
0
17
0
0
50
9
50
0
0
9
59
9
17
9
0
% N
% Pro:
9
0
0
9
9
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
9
0
0
42
0
0
0
% Q
% Arg:
0
0
0
0
9
0
9
0
9
0
9
0
0
9
0
% R
% Ser:
59
0
9
9
0
9
9
0
0
9
0
0
0
0
0
% S
% Thr:
9
0
0
0
0
9
0
0
0
0
0
0
0
0
9
% T
% Val:
0
0
0
0
9
0
9
9
34
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
50
0
0
0
0
59
9
0
0
9
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _